In 1928 the sound was first applied to animation by Walt Disney who saw the huge potential (Steamboat Willie was the first animation with synchronized sound). It was then suggested not only to use the sound but base entire animation on it.
Subsequently in 1929 The Skeleton Dance was created (entirely by one animator Ub Iwerks)
It‘s an animated short based little on the story, but heavily on the performance, that‘s as mentioned before, is directed by the music/sound.
It was the first of many series of the Silly Symphonies, animated shorts produced by Walt Disney Productions for the next 10 years. Looney Tunes cartoons known today were inspired by the Silly Symphonies.